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The Best Mushroom Supplements for Your Health (and why)

by Lauretta Iyamu, PharmD
June 2, 2025
Reading Time: 11 mins read
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Last Updated on June 2, 2025 by Lauretta Iyamu, PharmD

Are you feeling tired, stressed, or mentally foggy? Many people look for natural ways to improve energy, mental clarity, and overall health. This is where mushroom supplements come in.

They are packed with powerful compounds that can strengthen the immune system, improve brain function, and support heart health.

Imagine having more energy, better focus, and a stronger body simply by adding these supplements to your daily routine.

This article will cover the best mushroom supplements, their benefits, and how to choose the right one for you.

Learn more about the incredible benefits of mushroom supplements and how they can positively impact your health journey.

Table of Contents

Toggle
  • What Are Mushroom Supplements?
  • Types of Mushroom Supplements for Health
  • Best Mushroom Supplement Brands
  • Health Benefits of Mushroom Supplements
  • Choosing the Right Mushroom Supplement
  • How to Combine Mushroom Supplements into Your Diet
  • Potential Side Effects and Precautions
  • Wrapping Up
  • Frequently Asked Questions

What Are Mushroom Supplements?

best mushroom supplements in different forms on a table.
 

Mushroom supplements are products made from different types of mushrooms that you can take in various forms, like capsules, powders, or teas. They make it easy to get the health benefits of mushrooms without having to eat them all the time.

History of Medicinal Mushrooms

Medicinal mushrooms have been used for thousands of years in places like China and Japan to treat various illnesses and stay healthy. Modern science is discovering why these mushrooms are so special.

Today, people are turning to mushroom supplements because they are natural, have fewer side effects than some medications, and are easy to include in their daily routines.

What Makes Mushrooms Medicinal?

Medicinal mushrooms contain special compounds that help your body in different ways. These compounds include:

  • Polysaccharides: These boost your immune system.
  • Triterpenoids: These have anti-inflammatory properties.
  • Beta-Glucans: These help your body fight off infections.

Key Benefits of Medicinal Mushrooms

  • Immune Support: They help strengthen your immune system.
  • Brain Health: Some mushrooms improve memory and focus.
  • Anti-Inflammatory: They can reduce inflammation in your body.
  • Antioxidants: They protect your cells from damage.

Types of Mushroom Supplements for Health

Illustration of ancient Chinese medicine practices using mushrooms.
 

1. Reishi (Ganoderma lucidum)

Reishi mushrooms are known for their calming effects. They can help you relax, improve your sleep, and boost your immune system.

How to Use Reishi

You can take Reishi as a capsule, powder, or tea. For the best results, follow the instructions on the package.

2. Lion’s Mane (Hericium erinaceus)

Lion’s Mane is great for your brain. It can help improve your memory, focus, and mood.

How to Use Lion’s Mane

Lion’s Mane supplements come in capsules or powders. The powder can be added to coffee or smoothies.

3. Chaga (Inonotus obliquus)

Chaga mushrooms are packed with antioxidants. They help boost your immune system and protect your body from damage.

How to Use Chaga

Chaga supplements are available as powders, tinctures, and capsules. You can also make Chaga tea for a healthy drink.

4. Shiitake (Lentinula edodes)

Shiitake mushrooms are good for your heart. They can help lower cholesterol and support overall heart health.

How to Use Shiitake

Shiitake supplements come in capsules and powders. They are easy to add to your daily routine.

5. Maitake (Grifola frondosa)

Maitake mushrooms can help regulate blood sugar levels, which is great for overall health.

How to Use Maitake

Maitake supplements are usually in capsule form. They are simple to take with your meals.

Best Mushroom Supplement Brands

1. Life Cykel

Life Cykel prides itself on producing some of the highest-quality and bioavailable mushroom products. Its mission is to deliver the highest possible ethos attached to incredible, professional products to those who wish to upgrade their wellness and reach their true potential.

2. Host Defense

Host Defense specializes in mushroom mycelium-based supplements to support natural immunity and whole-body wellness. The company is one of the best-documented and longest-standing mushroom supplement companies in the USA.

3. Genius Mushroom

Genius mushroom supplements offer a wide range of mushroom products that help enhance mental clarity, support immune function, promote natural energy, and more. These organic mushrooms, grown in the USA, are keto, paleo, and vegan-friendly.

Health Benefits of Mushroom Supplements

1. Immune System Support

Medicinal mushrooms are famous for their ability to strengthen your immune system. They help your body fight off infections and stay healthy.

2. Cognitive Function and Mental Health

Mushrooms like Lion’s Mane can improve your brain function. They help with memory, focus, and even mood, making you feel better mentally.

3. Anti-Inflammatory Properties

Many mushrooms reduce inflammation in your body. This can help with conditions like arthritis and improve your overall health.

4. Antioxidant Effects

Mushrooms like Chaga are rich in antioxidants, which protect your cells from damage and keep you healthy.

5. Cardiovascular Health

Mushrooms such as Shiitake and Reishi support heart health by improving cholesterol levels and reducing the risk of heart disease.

6. Blood Sugar Regulation

Maitake mushrooms can help keep your blood sugar levels stable, which is important for preventing diabetes and other health issues.

Choosing the Right Mushroom Supplement

When picking a mushroom supplement, think about these factors:

  • Choose products made from pure mushroom extracts without fillers.
  • Pick brands that source mushrooms sustainably.
  • Decide if you prefer capsules, powders, or tinctures, and follow the recommended dosage.
  • Look for products tested for quality and certifications like organic or non-GMO.

Tips for Choosing

  • Make sure the brand is reputable.
  • Read reviews to see what other users think.
  • Talk to your doctor, especially if you have health conditions or take other medications.

How to Combine Mushroom Supplements into Your Diet

1. Morning Routine

Add Lion’s Mane powder to your morning coffee or smoothie for a brain boost.

2. Midday Boost

Take Reishi or Shiitake capsules with your lunch to support your immune system throughout the day.

3. Evening Relaxation

Drink Reishi tea in the evening to help you relax and improve your sleep quality.

For the best results, take your mushroom supplements consistently every day. It might take some time to see the benefits, so be patient.

Potential Side Effects and Precautions

While mushroom supplements are generally safe, some people might experience side effects.

You might experience digestive issues, such as nausea or bloating. If this happens, stop taking the supplement and talk to your doctor.

1. Allergic Reactions

If you’re allergic to mushrooms, avoid mushroom supplements. Watch for signs of an allergic reaction, like a rash or difficulty breathing.

2. Interactions with Medications

Mushroom supplements can interact with some medications. Always consult your doctor before starting any new supplement.

3. Pregnancy and Breastfeeding

If you’re pregnant or breastfeeding, talk to your healthcare provider before taking mushroom supplements to make sure they’re safe for you.

Wrapping Up

Mushroom supplements are a great way to improve your health naturally.

They offer many benefits, from supporting your immune system to improving your brain function.

When you understand the benefits of different mushrooms and know what to look for in a supplement, you can choose the best one for your needs.

Whether you want to strengthen your immune health, enhance your brain function, or support your heart health, there’s a mushroom supplement that can help you achieve your wellness goals.

Add mushroom supplements to your daily routine and enjoy their health benefits.

Frequently Asked Questions

What are the health benefits of mushroom supplements?

Mushroom supplements can support your immune system, improve brain function, reduce inflammation, and promote heart health. They’re a natural way to enhance your overall well-being.

How do I choose the best mushroom supplement?

Look for pure, sustainably sourced, and third-party-tested supplements. Check reviews and consult your doctor, especially if you have health conditions or take other medications.

Can mushroom supplements help with memory and focus?

Yes, mushrooms like Lion’s Mane are known to improve memory and focus. They can help boost your brain health and enhance cognitive function.

Are there any side effects of taking mushroom supplements?

Some people might experience digestive issues or allergic reactions. Always start with a small dose and consult your doctor if you have any concerns or experience any adverse effects.

How should I take mushroom supplements for the best results?

Take mushroom supplements consistently every day. You can add powders to your coffee or smoothies or take capsules with your meals. Follow the dosage instructions on the product label.

References

  1. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value, and Application in Functional Food Production—A Review. National Center for Biotechnology Information (NCBI), 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384337/
  2. Medicinal Mushrooms (PDQ®). National Cancer Institute (NCI), 2023. https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq
  3. The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress, and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.” National Center for Biotechnology Information (NCBI), 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675414/
  4. 7 Health Benefits of Mushrooms. UCLA Health, 2023. https://www.uclahealth.org/news/article/7-health-benefits-of-mushrooms
  5. Lion’s Mane Mushroom Powder for Brain Health. NutritionFacts.org, 2023. https://nutritionfacts.org/hnta-video/lions-mane-mushroom-powder-for-brain-health/
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